This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). AP-1 is a dimeric transcription factor composed of proteins belonging to the Jun (c-Jun, JunB, and JunD), Fos (c-Fos, FosB, Fra1 and Fra2) and activating transcription factor protein families.
This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).
The current subsections and their content are listed below:
The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review.Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a fatal malignancy known as adult T-cell leukemia (ATL). Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Supplementary
This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.
Phosphorylated at Thr-242, Ser-246 and Ser-252 by GSK3B; phosphorylation reduces its ability to bind DNA.
This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.
Manual assertion inferred from sequence similarity to Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.
This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein.
This section provides information on the tertiary and secondary structure of a protein.
The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:
It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.
Interacts with PRR7 and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (By similarity).
This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding lipids, glycans and protein cross-links.
Manual assertion inferred from sequence similarity toManual assertion inferred from sequence similarity to
In addition to the analysis of ATL-relevant signaling pathways, understanding the regulation of important and relevant transcription factors allows researchers to reach this fundamental objective. These are stable identifiers and should be used to cite UniProtKB entries.
This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.
In JunD expressing cells, HBZ is diffusely distributed throughout the nucleoplasm, while no HBZ-NBs are formed (In association with JunD and Sp-1, HBZ also activates the transcription of the human telomerase catalytic subunit gene (hTERT) (We recently uncovered an additional mechanism used by HBZ to turn JunD from a growth suppressor to a tumor promoter (JunD mRNA contains a third functional out-of-frame ORF (uORFs) positioned between the ATG of JunD-FL and ATG of ΔJunD (Activating protein-1 family members have both overlapping and unique roles, and the transcriptional activity of the AP-1 dimer functions in a tissue-specific fashion (Indeed, gene substitution experiments in mice have shown that growth retardation and osteoporosis observed in c-Fos null-mice were rescued by Fra-1 overexpression, although Fra-1 failed to induce expression of c-Fos target genes, such as MMP13 and vimentin (J-MP and HG wrote the first draft of the manuscript. Involved in activated KRAS-mediated transcriptional activation of USP28.
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